診療科・部門

臨床研究センター 先進医療研究開発部 業績

メイン画像 メイン画像 メイン画像 メイン画像 メイン画像 メイン画像 メイン画像 メイン画像 メイン画像

Department of Biomedical Research and Innovation


プレスリリース

 脳型ドレブリンを指標としたヒトiPS細胞由来神経細胞のシナプス成熟評価法の開発とシナプス形成過程の解明

英文業績

①原著論文

1. Kinoshita M, Uchikoshi M, Tateishi S, Miyazaki S, Sakai M, Ozaki T, Asai K, Fujita Y, Matsuhashi T, Kanemura Y, Shimosegawa E, Hatazawa J, Nakatsuka SI, Kishima H, Nakanishi K: Magnetic Resonance Relaxometry for Tumor Cell Density Imaging for Glioma: An Exploratory Study via 11C-Methionine PET and Its Validation via Stereotactic Tissue Sampling. Cancers (Basel) 13:4067, 2021

2. Fujimoto K, Arita H, Satomi K, Yamasaki K, Matsushita Y, Nakamura T, Miyakita Y, Umehara T, Kobayashi K, Tamura K, Tanaka S, Higuchi F, Okita Y, Kanemura Y, Fukai J, Sakamoto D, Uda T, Machida R, Kuchiba A, Maehara T, Nagane M, Nishikawa R, Suzuki H, Shibuya M, Komori T, Narita Y, Ichimura K: TERT promoter mutation status is necessary and sufficient to diagnose IDH-wildtype diffuse astrocytic glioma with molecular features of glioblastoma. Acta Neuropathol 142:323-338, 2021

3. Makino Y, Arakawa Y, Yoshioka E, Shofuda T, Kawauchi T, Terada Y, Tanji M, Kanematsu D, Mineharu Y, Miyamoto S, Kanemura Y: Prognostic stratification for IDH-wild-type lower-grade astrocytoma by Sanger sequencing and copy-number alteration analysis with MLPA. Sci Rep 11:14408, 2021

4. Inoue A, Nishikawa M, Ohnishi T, Yano H, Kanemura Y, Ohtsuka Y, Ozaki S, Nakamura Y, Matsumoto S, Suehiro S, Yamashita D, Shigekawa S, Watanabe H, Kitazawa R, Tanaka J, Kunieda T: Prediction of glioma stem-like cell infiltration in the non-contrast-enhancing area by quantitative measurement of lactate on magnetic resonance spectroscopy in glioblastoma. World Neurosurg S1878-8750(21)00875-5, 2021

5. Nishikawa M, Inoue A, Ohnishi T, Yano H, Ozaki S, Kanemura Y, Suehiro S, Ohtsuka Y, Kohno S, Ohue S, Shigekawa S, Watanabe H, Kitazawa R, Tanaka J, Kunieda T: Hypoxia-induced phenotypic transition from highly invasive to less invasive tumors in glioma stem-like cells: Significance of CD44 and osteopontin as therapeutic targets in glioblastoma. Transl Oncol 14:101137, 2021

6. Anami S, Fukai J, Hama M, Awaya A, Inagaki T, Chiba T, Noda Y, Kanemura Y, Nakao N, Sonomura T: Brainstem Infiltration Predicts Survival in Patients With High-grade Gliomas Treated With Chemoradiotherapy. Anticancer Res 41:2583-2589, 2021

7. Okada M, Kawagoe Y, Sato Y, Nozumi M, Ishikawa Y, Tamada A, Yamazaki H, Sekino Y, Kanemura Y, Shinmyo Y, Kawasaki H, Kaneko N, Sawamoto K, Fujii Y, Igarashi M: Phosphorylation of GAP-43 T172 is a molecular marker of growing axons in a wide range of mammals including primates. Mol Brain 14:66, 2021

8. Miyahara H, Natsumeda M, Kanemura Y, Yamasaki K, Riku Y, Akagi A, Oohashi W, Shofuda T, Yoshioka E, Sato Y, Taga T, Naruke Y, Ando R, Hasegawa D, Yoshida M, Sakaida T, Okada N, Watanabe H, Ozeki M, Arakawa Y, Yoshimura J, Fujii Y, Suenobu S, Ihara K, Hara J, Kakita A, Yoshida M, Iwasaki Y: Topoisomerase IIβ immunoreactivity (IR) co-localizes with neuronal marker-IR but not glial fibrillary acidic protein-IR in GLI3-positive medulloblastomas: an immunohistochemical analysis of 124 medulloblastomas from the Japan Children's Cancer Group. Brain Tumor Pathol 38:109-121, 2021

9. Takahashi S, Takahashi M, Kinoshita M, Miyake M, Kawaguchi R, Shinojima N, Mukasa A, Saito K, Nagane M, Otani R, Higuchi F, Tanaka S, Hata N, Tamura K, Tateishi K, Nishikawa R, Arita H, Nonaka M, Uda T, Fukai J, Okita Y, Tsuyuguchi N, Kanemura Y, Kobayashi K, Sese J, Ichimura K, Narita Y, Hamamoto R: Fine- Tuning Approach for Segmentation of Gliomas in Brain Magnetic Resonance Images with a Machine Learning Method to Normalize Image Differences among Facilities. Cancers (Basel). 13:1415, 2021

10. Ito N, Riyadh MA, Ahmad SAI, Hattori S, Kanemura Y, Kiyonari H, Abe T, Furuta Y, Shinmyo Y, Kaneko N, Hirota Y, Lupo G, Hatakeyama J, Abdulhaleem M FA, Anam MB, Yamaguchi M, Takeo T, Takebayashi H, Takebayashi M, Oike Y, Nakagata N, Shimamura K, Holtzman MJ, Takahashi Y, Guillemot F, Miyakawa T, Sawamoto K, Ohta K: Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice. Sci Transl Med 13:eaay7896, 2021

11. Nakajo K, Uda T, Kawashima T, Terakawa Y, Ishibashi K, Tsuyuguchi N, Tanoue Y, Nagahama A, Uda H, Koh S, Sasaki T, Ohata K, Kanemura Y, Goto T: Diagnostic Performance of [11C]Methionine Positron Emission Tomography in Newly Diagnosed and Untreated Glioma Based on the Revised World Health Organization 2016 Classification. World Neurosurg S1878-8750:00033-4, 2021

12. Kinoshita M, Arita H, Takahashi M, Uda T, Fukai J, Ishibashi K, Kijima N, Hirayama R, Sakai M, Arisawa A, Takahashi H, Nakanishi K, Kagawa N, Ichimura K, Kanemura Y, Narita Y, Kishima H: Impact of Inversion Time for FLAIR Acquisition on the T2-FLAIR Mismatch Detectability for IDH-Mutant, Non-CODEL Astrocytomas. Front Oncol 10:596448, 2021

13. Nishikawa M, Inoue A, Ohnishi T, Yano H, Kanemura Y, Kohno S, Ohue S, Ozaki S, Matsumoto S, Suehiro S, Nakamura Y, Shigekawa S, Watanabe H, Kitazawa R, Tanaka J, Kunieda T: CD44 expression in the tumor periphery predicts the responsiveness to bevacizumab in the treatment of recurrent glioblastoma. Cancer Med 10:2013-2025, 2021

14. Fukusumi H, Togo K, Sumida M, Nakamori M, Obika S, Baba K, Shofuda T, Ito D, Okano H, Mochizuki H, Kanemura Y: Alpha-synuclein dynamics in induced pluripotent stem cell-derived dopaminergic neurons from a Parkinson's disease patient (PARK4) with SNCA triplication. FEBS Open Bio 11: 354-366, 2021

15. Itai T, Miyatake S, Taguri M, Nozaki F, Ohta M, Osaka H, Morimoto M, Tandou T, Nohara F, Takami Y, Yoshioka F, Shimokawa S, Okuno-Yuguchi J, Motobayashi M, Takei Y, Fukuyama T, Kumada S, Miyata Y, Ogawa C, Maki Y, Togashi N, Ishikura T, Kinoshita M, Mitani Y, Kanemura Y, Omi T, Ando N, Hattori A, Saitoh S, Kitai Y, Hirai S, Arai H, Ishida F, Taniguchi H, Kitabatake Y, Ozono K, Nabatame S, Smigiel R, Kato M, Tanda K, Saito Y, Ishiyama A, Noguchi Y, Miura M, Nakano T, Hirano K, Honda R, Kuki I, Takanashi JI, Takeuchi A, Fukasawa T, Seiwa C, Harada A, Yachi Y, Higashiyama H, Terashima H, Kumagai T, Hada S, Abe Y, Miyagi E, Uchiyama Y, Fujita A, Imagawa E, Azuma Y, Hamanaka K, Koshimizu E, Mitsuhashi S, Mizuguchi T, Takata A, Miyake N, Tsurusaki Y, Doi H, Nakashima M, Saitsu H, Matsumoto N: Prenatal clinical manifestations in individuals with COL4A1/2 variants. J Med Genet 58:505-513, 2021

16. Kinoshita M, Uchikoshi M, Sakai M, Kanemura Y, Kishima H, Nakanishi K: T2-FLAIR Mismatch Sign Is Caused by Long T1 and T2 of IDH-mutant, 1p19q Non-codeleted Astrocytoma. Magn Reson Med Sci 20:119-123, 2021

17. Achiha T, Kijima N, Kodama Y, Kagawa N, Kinoshita M, Fujimoto Y, Nonaka M, Fukai J, Inoue A, Nishida N, Yamanaka T, Harada A, Mori K, Tsuyuguchi N, Uda T, Ishibashi K, Tomogane Y, Sakamoto D, Shofuda T, Yoshioka E, Kanematsu D, Mano M, Luu B, Taylor MD, Kanemura Y, Kishima H: Activated leukocyte cell adhesion molecule expression correlates with the WNT subgroup in medulloblastoma and is involved in regulating tumor cell proliferation and invasion. PLoS One 15:e0243272, 2020

18. Arita H, Matsushita Y, Machida R, Yamasaki K, Hata N, Ohno M, Yamaguchi S, Sasayama T, Tanaka S, Higuchi F, Iuchi T, Saito K, Kanamori M, Matsuda KI, Miyake Y, Tamura K, Tamai S, Nakamura T, Uda T, Okita Y, Fukai J, Sakamoto D, Hattori Y, Pareira ES, Hatae R, Ishi Y, Miyakita Y, Tanaka K, Takayanagi S, Otani R, Sakaida T, Kobayashi K, Saito R, Kurozumi K, Shofuda T, Nonaka M, Suzuki H, Shibuya M, Komori T, Sasaki H, Mizoguchi M, Kishima H, Nakada M, Sonoda Y, Tominaga T, Nagane M, Nishikawa R, Kanemura Y, Kuchiba A, Narita Y, Ichimura K: TERT promoter mutation confers favorable prognosis regardless of 1p/19q status in adult diffuse gliomas with IDH1/2 mutations. Acta Neuropathol Commun 8:201, 2020

19. Kikuchi Z, Shibahara I, Yamaki T, Yoshioka E, Shofuda T, Ohe R, Matsuda KI, Saito R, Kanamori M, Kanemura Y, Kumabe T, Tominaga T, Sonoda Y: TERT promoter mutation associated with multifocal phenotype and poor prognosis in patients with IDH wild-type glioblastoma. Neurooncol Adv 2:vdaa114, 2020

20. Okita Y, Shofuda T, Kanematsu D, Yoshioka E, Kodama Y, Mano M, Kinoshita M, Nonaka M, Fujinaka T, Kanemura Y: The association between 11 C-methionine uptake, IDH gene mutation, and MGMT promoter methylation in patients with grade II and III gliomasClin Radiol 75:622-628, 2020

21. Fukai J, Arita H, Umehara T, Yoshioka E, Shofuda T, Kanematsu D, Kodama Y, Mano M, Kinoshita M, Okita Y, Nonaka M, Uda T, Tsuyuguchi N, Sakamoto D, Uematsu Y, Nakao N, Mori K, Kanemura Y: Molecular characteristics and clinical outcomes of elderly patients with IDH-wildtype glioblastomas: comparative study of older and younger cases in Kansai Network cohort. Brain Tumor Pathol 37:50-59, 2020

22. Takami H, Fukushima S, Aoki K, Satomi K, Narumi K, Hama N, Matsushita Y, Fukuoka K, Yamasaki K, Nakamura T, Mukasa A, Saito N, Suzuki T, Yanagisawa T, Nakamura H, Sugiyama K, Tamura K, Maehara T, Nakada M, Nonaka M, Asai A, Yokogami K, Takeshima H, Iuchi T, Kanemura Y, Kobayashi K, Nagane M, Kurozumi K, Yoshimoto K, Matsuda M, Matsumura A, Hirose Y, Tokuyama T, Kumabe T, Ueki K, Narita Y, Shibui S, Totoki Y, Shibata T, Nakazato Y, Nishikawa R, Matsutani M, Ichimura K; Intracranial Germ Cell Tumor Genome Analysis Consortium (the iGCT Consortium): Intratumoural Immune Cell Landscape in Germinoma Reveals Multipotent Lineages and Exhibits Prognostic Significance. Neuropathol Appl Neurobiol 46:111-124, 2020

23. Yamaki T, Shibahra I, Matsuda KI, Kanemura Y, Konta T, Kanamori M, Yamakawa M, Tominaga T, Sonoda Y: Relationships between recurrence patterns and subventricular zone involvement or CD133 expression in glioblastoma. J Neurooncol 146:489-499, 2020

②症例報告

1. Okamoto N, Miya F, Kitai Y, Tsunoda T, Kato M, Saitoh S, Kanemura Y, Kosaki K: Homozygous ADCY5 mutation causes early-onset movement disorder with severe intellectual disability. Neurol Sci 42:2975-2978, 2021

2. Kijima N, Miuro S, Terada E, Nakagawa R, Tachi T, Murakami K, Okita Y, Kanemura Y, Nakajima S, Fujinaka T: Endovascular Treatment for Middle Cerebral Artery Aneurysms: Single-Center Experience and Review of Literatures. Journal of Neuroendovascular Therapy 15:213-219, 2021

3. Mitani Y, Fukuoka K, Mori M, Arakawa Y, Matsushita Y, Hibiya Y, Honda S, Kobayashi M, Tanami Y, Kanemura Y, Ichimura K, Nakazawa A, Kurihara J, Koh K: Clinical Aggressiveness of TP53-Wild Type Sonic Hedgehog Medulloblastoma With MYCN Amplification, Chromosome 17p Loss, and Chromothripsis. J Neuropathol Exp Neurol 80:205-207, 2021

4. Li Y, Nonaka M, Kanemura Y, Kodama Y, Mano M, Asai A: A case of medulloblastoma in a patient with fetal ventricular enlargement. Childs Nerv Sys 37:977-982, 2021

5. Miura S, Kijima N, Fujimori N, Nakagawa T, Nakagawa R, Tachi T, Okita Y, Kanemura Y, Nakajima S, Mano M, Kishima H, Ozawa K, Fujinaka T: Surgical Treatment of Brain Metastasis of Extramammary Paget's Disease: A Case Report. NMC Case Rep J 7:189-193, 2020

6. Aoki T, Kishimoto H, Hirato J, Kanemura Y, Mori M, Arakawa Y, Kurihara J, Oguma E, Koh K: A 21-month-old boy with vomiting, gait disturbance, and abnormal ocular alignment. Brain Pathol 30:425-426, 2020

7. Yotsumoto Y, Harada A, Tsugawa J, Ikura Y, Utsunomiya H, Miyatake S, Matsumoto N, Kanemura Y, Hashimoto-Tamaoki T: Infantile macrocephaly and multiple subcutaneous lipomas diagnosed with PTEN hamartoma tumor syndrome. Mol Clin Oncol 12:329-335, 2020

③総説

1. Kinoshita M, Kanemura Y, Narita Y, Kishima H: Reverse Engineering Glioma Radiomics to Conventional Neuroimaging. Neurol Med Chir (Tokyo). 2021 Aug 6. Online ahead of print

2. Shofuda T, Kanemura Y: HDACs and MYC in medulloblastoma: how do HDAC inhibitors control MYC-amplified tumors? Neuro Oncol 23:173-174. 2021

④著書

1. Yamasaki M, Kanemura Y: X-Linked Hydrocephalus. Textbook of Pediatric Neurosurgery (Editors: Di Rocco, Concezio, Pang, Dachling, Rutka, James T) 1-14, Springer International Publishing Copyright Holder Springer Nature Switzerland AG, 2020

和文業績


①原著論文

1. 館 哲郎,藤中俊之, 西本渓佑, 山崎弘輝, 村上皓紀, 高野浩司, 木谷知樹, 金村米博, 中島 伸:症候性内頸動脈瘤に対するPipeline Embolization Deviceの治療成績.脳神経外科ジャーナル29:864-869, 2020

②総説

1. 荒川芳輝,金村米博:外視鏡を用いた脳神経外科手術の現状と今後の展望 脳神経外科手術をより安全で正確な治療として進化させることが期待される(Q&A)  週刊日本医事新報 5046:51-52, 2021

2. 金村米博,永根基雄:分子分類時代における髄芽腫の治療法選択は? 新たな分類に基づいた、治療強度の最適化と有効な治療法の開発が望まれる(Q&A) 週刊日本医事新報 5033:51-53, 2020

3. 金村米博:総論 悪性脳腫瘍の基礎から臨床の現状.Medical Science Digest 46:3-5, 2020

4. 金村米博:NHOにおける臨床研究法の取り組みについて-認定臨床研究審査委員会の委員長の立場から-.医療74:283-287, 2020

③著書

1. 金村米博:小児脳腫瘍における遺伝子異常.脳神経外科速報 2020年増刊 悪性脳腫瘍のすべて-Neuro-Oncologyの教科書-遺伝子診断時代の臨床リアルワールド(杉山一彦,橋本直哉 編集),P. 30-38, 株式会社メディカ出版,2020